In H1299 cells, missing both Fhit and p53, Fdxr overexpression increases the sensitivity to ROS-induced cell death and H1299 cells expressing inducible Fhit or p53, are sensitive to ROS-induced cell death; cancer cells missing Fhit, p53, or both would lack ways to increase Fdxr expression, would be less sensitive to oxidative damage, and would survive. The gene discussed is TP53; the disease is cancer.