Since another very recent report38 showed that an inhibitor of OXPHOS, IACS-010759, a small-molecule inhibitor of ETC complex I, inhibited proliferation and induced apoptosis of brain cancer and AML cancer cells, which are dependent on OXPHOS, we were encouraged to try treatment of our Fhit-positive and Fhit-negative lung cancer cells with atovaquone, the ETC III inhibitor, with the idea that Fhit-negative cells may be dependent on OXPHOS for energy metabolism and survival. Here, FHIT is linked to brain cancer.