In H1299 cells, missing both Fhit and p53, Fdxr overexpression increases the sensitivity to ROS-induced cell death and H1299 cells expressing inducible Fhit or p53, are sensitive to ROS-induced cell death; cancer cells missing Fhit, p53, or both would lack ways to increase Fdxr expression, would be less sensitive to oxidative damage, and would survive. This evidence concerns the gene FHIT and cancer.