FHIT and cancer: Fhit restoration by stable transfection in cancer cells has little effect on cell growth in vitro, unless cells are exposed to stress, including the stress of the nude mouse environment in vivo;10 viral-mediated Fhit restoration, a process that simultaneously supplies stress and Fhit expression, suppresses tumorigenesis in vivo and triggers apoptosis of many types of malignant cells in vitro11–14, including lung cancer cells.