Previously, Wang et al reported that lncRNA ZNFX1-AS1 acted as a tumor suppressor and inhibited the growth of hepatocellular carcinoma cells27, this implies that lncRNA ZNFX1-AS1 expression pattern may be tissue and cell-specific, and lncRNA ZNFX1-AS1 can be oncogenic or tumor-suppressive depending on the tumor type and cellular microenvironment. This evidence concerns the gene ZNFX1 and hepatocellular carcinoma.