NR1H3 and nonpapillary renal cell carcinoma: Additionally, LXRα effectively differentiated ccRCC from paracancerous normal tissues with an area under the curve (AUC) of 0.8829 (95% CI: 0.8241–0.9418; p < 0.0001), and LXRα expression may be a potential diagnostic biomarker for ccRCC patients with (T1+T2) VS (T3+T4) stage and (G1+G2) VS (G3+G4) stage according to the results of ROC curves (Fig. 1d).