To examine whether the knockdown of NLRP3 could interrupt the inhibitory effects on aggressiveness caused by LXRα knockdown in ccRCC cells, we performed rescue experiments by co-transfecting with sh-LXRα lentivirus (vs. the negative control) and si-NLRP3 (vs. the negative control) into ACHN and 786-O cells. The gene discussed is NR1H3; the disease is nonpapillary renal cell carcinoma.