Although bioinformatics analysis of LXR (LXRα and LXRβ) expression in ccRCC indicated that both LXRα and LXRβ mRNA expression in ccRCC cancer tissue was higher than that in corresponding adjacent normal tissues, the elevated degree of LXRα expression in ccRCC cancer tissues compared with normal kidney were much higher than those of LXRβ (Fig. 1a, Fig. S1A). The gene discussed is NR1H3; the disease is cancer.