NLRP3 and nonpapillary renal cell carcinoma: Besides, according to the results of transwell migration and invasion assays in 786-O and ACHN that were cotransfection with sh-LXRα (vs. the negative control) and si-NLRP3 (vs. the negative control), we confirmed that knockdown of NLRP3 could reverse the inhibitory effect in ccRCC cell metastasis caused by knockdown of LXRα (Fig. 4b).