Previous studies showed that CTGF plays an important role in the occurrence and development of hepatic fibrosis, which not only directly induces the activation, proliferation and migration of hepatic stellate cells, but also promotes the synthesis and secretion of extracellular matrix and activation of hepatic stellate cells; therefore the proportion of extracellular collagen changes in liver, and the type I and III collagen fibers especially type I collagen significantly increase [28, 29]. The gene discussed is CCN2; the disease is Hepatic fibrosis.