The IGF1 could induce fibrosis through the Ras signaling pathway, HIF-1 signaling pathway, p53 signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, MAPK signaling pathway, focal adhesion, hypertrophic cardiomyopathy and other signaling pathways. This evidence concerns the gene AKT1 and hypertrophic cardiomyopathy.