We observed a dramatic reduction of LEF1‐AS1 expression in MDS and AML patients when compared to healthy bone marrow donors (controls = 15, MDS patients = 12, fivefold reduction, P = 0.0042, AML patients = 28, sevenfold reduction, P < 0.0001) (Figure 1G). The gene discussed is LEF1; the disease is myelodysplastic syndrome.