A recent study identified an unprocessed non‐coding transcript in the locus and demonstrated that this transcript regulates LEF1 coding expression in pancreatic and colorectal carcinoma cell lines.6 The function of LEF1‐AS1 in these cell lines was dependent on the unspliced transcript and ultimately on the regulation of LEF1.6 Based on this evidence and as LEF1 coding gene has an established role in myeloid malignancy,7, 8 we suspected a cis‐regulatory mechanism between the antisense non‐coding transcript and LEF1 in the haematopoietic system. This evidence concerns the gene LEF1 and colorectal carcinoma.