The suppression of LEF1 in myelodysplastic syndrome is well documented8; however, the expression pattern of LEF1 in AML had been less clear, and high expression of LEF1 has been associated with a favourable prognosis in a subtype of AML.15 Here, we show that LEF1 is suppressed in a heterogenous sample of AML and we could not correlate expression of LEF1 with patient outcome. This evidence concerns the gene LEF1 and myelodysplastic syndrome.