Compared to C. albicans WO-1, C. albicans SC5314 holds the following differences for the infection mechanisms: (1) TF orf19.4433 (CPH1) regulates gene orf19.666 to cause DNA damage response; (2) TF Jun with methylation and ubiquitination regulates gene MMP12 to bring about ECM degradation; (3) TF FOS only with ubiquitination regulates gene MMP12 to have ECM degradation; (4) TF FOXA1 regulates gene SERPINF1 instead of VMP1 to result in apoptosis; (5) miR1979-2 rather than miR210 represses gene CCDC22 to do inflammatory response. Here, SERPINF1 is linked to infection.