Compared to C. albicans SC5314, C. albicans WO-1 takes the following differences for the infection mechanisms: (1) TF CAWG_02083 (EFG1) regulates gene CAWG_00418 (WOR1) to cause a white-opaque switch; (2) FOS with ubiquitination and methylation regulates gene MMP12 to contribute to ECM degradation. The gene discussed is TF; the disease is infection.