As shown in Figure 1, in the infection progression of C. albicans SC5314, orf19.1816 (ALS3) plays a significant role in cell adhesion and endocytosis induction by interacting with EGFR, ERBB2 (HER2), CDH1 (E-cadherin), HSP90B1 and TJAP1 (TJP4) [8,9,10,11]. The gene discussed is EGFR; the disease is infection.