SDHB and metastatic neoplasm: In a recent, comprehensive analysis of The Cancer Genome Atlas (TCGA) database, genomic markers associated with metastatic disease (distant metastases, local recurrence or positive regional lymph nodes) included SDHB germline mutations, MAML3 fusion gene variants, somatic mutations in SETD2 or ATRX, a high number of somatic mutations in total, a hypermethylation subtype and the two mRNA subtypes: the Wnt-altered and the pseudohypoxia [37].