In CEFs, significant enrichment was seen in pathways including the MAPK signaling pathway (FOS/IL1B/FOSB), the toll-like receptor signaling pathway (FOSB, IL8L1, IL1B, FOS, CCL5), influenza A (IL8L1/IL1B/CCL5), cytokine–cytokine receptor interactions (CCL20/IL8L1/IL1B/CX3CR1/CCL5), salmonella infection (FOSB/IL8L1/IL1B/FOS), the NOD-like receptor signaling pathway (IL8L1/IL1B/CCL5), and herpes simplex infection (FOSB/IL1B/FOS/CCL5) (Figure 5A). The gene discussed is IL1B; the disease is herpes simplex infectious disease.