Cancer cells with mutations and/or abnormal expression in proto-oncogenes and/or suppressors with hyperactivation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways, which are the most frequently dysregulated signaling pathways in human cancers, have been shown to be more susceptible to Ran knockdown than normal cells [7]. Here, AKT1 is linked to cancer.