Although CARP-1 functions as a co-activator of steroid/thyroid nuclear receptors to promote growth [7], and co-activates β-Catenin in colon cancer cells to promote metastasis [8], its transcriptional co-activation of tumor suppressor p53 regulates apoptosis by Adriamycin [7]. The gene discussed is CCAR1; the disease is colonic neoplasm.