AKT1 and cancer: To date, a few studies have indicated that stellettin B induces apoptotic cell death through inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway in human cancers, as demonstrated in glioblastoma cancer SF295 cells [5], human non-small-cell lung cancer cells [6], and human chronic myeloid leukemia cells [7].