In GBM, the EGFR-dependent signaling pathway, phosphoinositide 3-kinase (PI3K)/Akt, and signal transducer and activator of transcription-3 (Stat3) signaling are frequently overexpressed [12], which regulates cell angiogenesis, proliferation, adhesion, and migration [13]. The gene discussed is STAT3; the disease is glioblastoma.