SLC1A2 and peripheral nerve injury: Given that the analgesic effects of gabapentin rely on the expression of GLT-1 in the LC, which is down-regulated during the chronification of neuropathic pain [39,43], the early uniform antihypersensitivity effect of gabapentin decreases over time in rats after peripheral nerve injury and nearly 80% of its efficacy is lost eight weeks after injury, associated with down-regulation of GLT-1 in the LC [43].