They include five proteins associated with the epidermal growth factor receptor (EGFR) pathway, known to be deregulated in bladder cancer: Eps15 Homology (EH)-domain-containing protein 4, epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1), epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8L2), Guanosine-5′-triphosphate hydrolyzing enzyme NRas (GTPase NRas), and mucin 4. The gene discussed is EPS8L1; the disease is urinary bladder carcinoma.