MRE11 in isolation was not a prognostic factor, but when combined with RAD51, low expression of both proteins was significantly associated with better response to oxaliplatin, which is part of the Leucovorin, 5-Fluorouracil, and Oxaliplatin (FOLFOX) regimen as first-line treatment for advanced colorectal cancer [40,54]. Here, MRE11 is linked to colorectal cancer.