Studies have reported an inverse relationship between muscular strength with both traditional and emerging CVD risk factors such as insulin resistance, systolic blood pressure, lipid-metabolic index (triglyceride, low density lipoprotein cholesterol; LDL-cholesterol, HDL-cholesterol, and glucose concentrations), clustered metabolic risk (sum of z-scores of waist circumference, systolic blood pressure, triglycerides, total cholesterol/HDL-cholesterol ratio, and insulin resistance), and C-reactive protein, complement component 3 (C3), and ceruloplasmin [39,50,51]. The gene discussed is C3; the disease is Insulin resistance.