Similarly, the up-regulated genes in the ABCB5 CTC fractions were involved in metastasis (CALU, CYB5R1, DUSP3, CREG1, ENDOD1), tumour growth, and/or melanoma biology (H1F0, SCNA, WIPI1, TXN2) [42,43,54,55,56,57,58,59,60]. This evidence concerns the gene CALU and melanoma.