However, DDIT3 was up-regulated as a result of the apoptotic activity triggered by the compound HA15 in melanoma cell lines [45], as was SEC31A, [45] a gene found up-regulated in MCSP CTC fractions, Altogether, the role of WIPI1 and DDIT3 may indicate common molecular mechanisms in CTC biology. The gene discussed is WIPI1; the disease is melanoma.