Recent studies have demonstrated that CCL18 specifically binds to PITPNM3 on the cellular membrane of breast cancer cells and hepatocellular carcinoma to exert its biological effects.9, 10, 11, 12, 13, 14 CCL18 also acts on a variety of target molecules, including VCAM‐1, AMAP1 and ACAP4.24, 40, 46 In our study, SCCHN cells with high PITPNM3 expression were chosen for transfection with rhCCL18. The gene discussed is PITPNM3; the disease is hepatocellular carcinoma.