CDH1 and head and neck squamous cell carcinoma: EMT has been demonstrated to play a pivotal role in the process of cell migration and invasion in a variety of cancer types including SCCHN.37, 45, 52 Cancer cells that undergo EMT are characterized by down‐regulation of cell‐cell adhesion molecules, such as E‐cadherin, and up‐regulation of Vimentin and N‐cadherin.37