EMT has been demonstrated to play a pivotal role in the process of cell migration and invasion in a variety of cancer types including SCCHN.37, 45, 52 Cancer cells that undergo EMT are characterized by down‐regulation of cell‐cell adhesion molecules, such as E‐cadherin, and up‐regulation of Vimentin and N‐cadherin.37 Here, CDH2 is linked to head and neck squamous cell carcinoma.