MTDH and metastatic malignant neoplasm in the lymph nodes: Our previous studies have also confirmed that overexpression of MTDH is highly correlated with lymph node metastasis and shows negative association with poor prognosis in SCCHN patients.38, 39 MTDH has been demonstrated to be a valuable biomarker for SCCHN progression, and it regulates the metastasis of SCCHN via EMT in vitro.38, 40