NF‐κB signalling pathway has also been demonstrated to play an important role in malignant cell mobility.41, 42, 43, 44 Accumulated evidence suggests that MTDH mediates the biological effect of the NF‐κB signalling pathway through several mechanisms.45 However, it is unknown whether the NF‐κB signalling pathway is involved in the regulation of metastasis by CCL18 in SCCHN cells. The gene discussed is CCL18; the disease is head and neck squamous cell carcinoma.