MAPT and Alzheimer disease: A number of data have shown that metformin offers a protection against AD, likely through different mechanisms, including the inhibition of Aβ fibril deposition (Markowicz‐Piasecka et al., 2017), a protein phosphatase 2‐mediated reduction of tau phosphorylation (Kickstein et al., 2010), and a promotion of neurogenesis through the activation of an atypical PKC‐CBP pathway (Wang et al., 2012).