High AZIN2 expression in CRC was a sign of unfavorable prognosis (p<0.0001, log-rank test); 5-years DSS for patients with high AZIN2 tumor expression was 52.5% (95 CI 42.0–58.0) compared to 66.9% (95% CI 52.9–72.1) for those with low expression. The gene discussed is AZIN2; the disease is neoplasm.