INS and type 1 diabetes mellitus: Some contributions concentrated more on the insulin secretion mechanisms [15, 16, 30], others more with short-term modelling of perturbation experiments [9, 10, 13, 14, 31], and some publications describe more complex models, from multi-organ models [8, 32] to maximal models for in-silico Type 1 diabetes virtual patient simulation [33–37].