TP53 and neoplasm: Although the p53-knockout ID8 derivative cell line, F3, exhibited a lower virus-induced cytotoxicity and replication compared to a highly susceptible human cancer line, A549 (Fig. 3), the levels were comparable to those obtained with GL261, a mouse murine cell line that has shown utility as a syngeneic model vis-à-vis induction of anti-tumor immunization.