TARDBP and amyotrophic lateral sclerosis: Given that TDP-43 localizes to SGs [32, 38], and that aberrant SG responses have been implicated in the pathogenesis of c9FTD/ALS [6, 8, 20], we investigated whether the expression of (G4C2)149 in the murine CNS was associated with the abnormal deposition of SG-resident proteins.