MAPT and Alzheimer disease: Based on the striking success and safety profile of recent ASO-based clinical trials and, and the recent in vivo ASO-based tau reduction work by de Vos and colleagues [80], a clinical trial of IONIS-MAPTRx (BIIB080, ISIS 814907), the first ASO targeting tau in mild AD patients, is currently under way [ClinicalTrials.gov Identifier: NCT03186989].