From these genetic studies, the identification of common genetic variation in MAPT emerged, defining the H1 haplotype, that is a strong risk factor for primary tauopathies with dominant 4R-tau pathology, progressive supranuclear palsy (PSP; OR = 5.46) [19, 139, 260] and corticobasal degeneration (CBD; OR = 3.7) [139, 147, 171] and, more surprisingly, Parkinson’s disease (OR = 0.77) [306]. Here, MAPT is linked to progressive supranuclear palsy.