In comparison with passive tau immunotherapy, there are only two tau active vaccines that have been tested in human clinical trials, AADvac1 for Alzheimer’s disease and non-fluent primary progressive aphasia (Axon Neuroscience SE), and ACI-35 vaccine for Alzheimer’s disease (AC Immune SA, Janssen). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.