This protection extended to seizures independent of AD pathology with ASO-mediated knockdown of endogenous tau in adult non-transgenic mice [81] and in mouse (Kcna1−/−) and Drosophila (kcc and eas) models of hyperexcitability [141] as well as a mouse model for Dravet syndrome [112]. The gene discussed is MAPT; the disease is Alzheimer disease.