When applied to ‘omics datasets that we collected from Washington University lymphoma patients [21], or to publicly available cancer (TCGA) [26, 27] or ENCODE datasets [1, 28], PLAIDOH accurately identified and prioritized well-known lncRNA-target gene regulatory pairs (e.g., HOTAIR and HOX genes, PVT1 and MYC) [29–35], positive hits in a CRISPRi lncRNA growth screen [28], and lncRNA-protein binding partners (e.g., NEAT1 and NONO) [36]. The gene discussed is HOTAIR; the disease is cancer.