ADAP2 and neurofibromatosis type 1: The cancer-recurrent pattern for an LCP is exemplified in the EVI2/ADAP2 17q11.2 locus (Fig. 5f-h), which is associated with Neurofibromatosis type 1 microdeletion syndrome, a severe phenotype with overgrowth and increased neurofibromas [67, 68].