SLCO1B3 and cervical squamous intraepithelial neoplasia: The dose-dependent effect of the nitrenium ion suggests that metabolism, bioavailability or other factors relating to pharmacokinetics could be related to CIA and CIN, a hypothesis supported by recent association of genetic variants in the hepatic transporter gene SLCO1B3. However, the relationship between clozapine dose and agranulocytosis remains unclear [27].