RB1 and neoplasm: Mutations of RB1 in samples detected were mainly CNVs, although the most common type of genes alterations was single nucleotide variations (SNV; 75%) in plasma, SNV (54%) in sputum, and CNV (52%) in urine (Figure 5A), the patients diagnosed with SNVs were still the majority of all detected by any kind of sample and the percentage of patients with CNVs were similar in sputum (45%), urine (43%), and tumor tissue (52%), P = 0.651 (Figure 5B).