Intriguingly, Peng Yang et al also found similar result in nonsmall cell lung cancer that elevated CD4+ naïve/memory ratio, rather than the other five immune parameters, correlated with prolonged progression‐free survival (P = 0.013).22 These results suggested that the ratio, rather than absolute count of naïve and memory T cells was more suitable to reveal the systemic inflammatory response to cancer. This evidence concerns the gene CD4 and cancer.