We next investigated whether the calpain‐dependent cleavage of DLP1 is present in neurons of CRND8 mice, a widely used APP transgenic (Tg) mouse model expressing the APP Swedish (KM670/671NL) and APP Indiana (V717F) mutations that shows early signs of memory impairment as well as striking amyloid plaque pathology (Yin et al., 2018). Here, APP is linked to memory impairment.