Our study showed that ARG1 was noticeably overexpressed in patients compared to healthy controls, consistent with the results of previous studies showing M2 activation in cryptococcal meningitis patients.41 Although the asthma and p53 signaling pathways were previously reported to be related to cryptococcal infection,39, 42 new related pathways, including the one carbon pool by folate, allograft rejection, and biosynthesis of unsaturated fatty acids pathways, were identified in this study. This evidence concerns the gene ARG1 and asthma.