Interestingly, in human glioblastoma tumor samples, an association was suggested between HMG-CoA-reductase (HMGCR), the rate-limiting enzyme in cholesterol biosynthesis, and LAMP2, a suggested marker for acidosis [30], further supporting a dependency of acidic cancer cells on cholesterol levels and that this pathway is a relevant therapeutic target of stressed tumor niche [95]. This evidence concerns the gene HMGCR and neoplasm.