BDNF and hypertensive disorder: Goel et al. showed the evidence that chronic neuroinflammation and memory impairment in hypertension—associated with increased apoptotic cell death and with amyloid beta deposition—can be prevented with candesartan treatment, suggesting partly to be explained by an increase of BDNF/CREB (cAMP response element binding protein) expression (Goel et al. 2017).