Taken together, the fact that plasma NGF level is reduced in chronic (Chaldakov et al. 2004) as well as in acute stages of human coronary atherosclerosis (Manni et al. 2005), suggests the role of NT deficiency in the pathophysiology of atherosclerosis and the association of NGF with CV diseases (Manni et al. 2005). The gene discussed is NGF; the disease is coronary atherosclerosis.