In accordance with the lower NAFLD score on HFD, mRNA expression levels of representative macrophage/inflammatory markers (F4/80, −26%; integrin alpha X, −36%) and markers for hepatic fibrosis (collagen type I alpha 1, −50%; collagen type I alpha 2, −38%; transforming growth factor beta, −23%) were significantly decreased (Fig. 4B, left panel). Here, COL1A1 is linked to metabolic dysfunction-associated steatotic liver disease.