CXCL8 seems to be implicated in CADM and ILD since serum level was increased in CADM compared to that in classical DM with ILD and HD [52] and in RP-ILD but not in C-ILD compared to non-ILD [65] or in ILD compared to non-ILD in anti-MDA5 or anti-ARS-Ab-positive patients [62]; however, in this last study, in multiple linear regression analysis CXCL8 was not associated with ILD. This evidence concerns the gene IFIH1 and interstitial lung disease.