Finally, a systematic meta-analysis found pooled sensitivity, specificity, and AUC values of 0.83 (95% CI: 0.77–0.88), 0.86 (95% CI: 0.80–0.91), and 0.87 (95% CI: 0.84–0.90) for anti-MDA5 Ab in DM with RPILD versus without RPILD [25]. The gene discussed is IFIH1; the disease is dermatomyositis.