BTG3 and synovial sarcoma: According to the 2012 American College of Rheumatology (ACR) classification criteria, significant dry eye must be present with either positive serology [anti-SSA and/or anti-SSB or a combination of rheumatoid factor (RF) and antinuclear antibody (ANA) at a titer ≥ 1 : 320] or a positive minor salivary gland biopsy to allow a diagnosis of SS [7].