An additional trial conducted by Grey, Boland, Davidson, Li, and Tamborlane (2000) also delivered coping skills training and stress management interventions to adolescents with T1D, but the intervention was delivered conjointly with changes in medical management (transition to an intensive insulin regimen), so that the independent impact of the stress management intervention could not be assessed. The gene discussed is INS; the disease is type 1 diabetes mellitus.