Among women who met clinical diagnostic criteria for depressive disorder, increased levels of FSH and LH, decreased levels of inhibin b, and increased variability of estradiol and FSH were significant associated with the first occurrence of depression in the menopause transition (estradiol variability: OR 2.45; 95 % CI: 1.54 – 3.89). The gene discussed is BRD2; the disease is depressive symptom measurement.