Interestingly, miR-219-5p negatively modulates several targets, including glypican-3, epidermal growth factor receptor (EGFR), estrogen α and sall4, which are all involved in tumorigenesis of HCC, glioblastoma, PTC and colon cancer [10, 22, 23, 25]. This evidence concerns the gene GPC3 and glioblastoma.