For example, rs1080985 in CYP2D6 corresponds to the -1584C > G variant that is linked to the low-expression CYP2D6∗41 allele (Raimundo et al., 2000; Raimundo et al., 2004); the PON1 rs854552 variant had been found in a nutrigenetic approach on markers of cardiovascular disease (Rizzi et al., 2016); and the AOC1 (diamine oxidase) variant rs10156191 was associated with hypersensitivity response to non-steroidal anti-inflammatory drugs (Agúndez et al., 2012). This evidence concerns the gene CYP2D6 and cardiovascular disorder.