STING pathway activation (Figure 2) occurs when DNA from tumor cells taken up by APCs is sensed by cyclic-GMP-AMP (cGAMP) synthase, which interacts directly with STING to induce a conformational change leading to translocation of STING from the endoplasmic reticulum to perinuclear vesicles (29). The gene discussed is STING1; the disease is neoplasm.