LAMP1 and infection: As shown in Figure 2E and Figures S1E,F, the colocalization of MAB-R with LAMP-1 was significantly lower than that of MAB-S (Figure 2F) at the 4 h.p.i and 24 h.p.i. Furthermore, colocalization intensity between MAB-R strains and LAMP-1 were decreased according to increase of infection time (4 to 24 h.p.i) (Figures S1E,F), strongly supporting our TEM based finding of phagosome escape of MAB-R strains.