Pathogenic mutations in PLCG2 lead to two distinct phenotypes: PLCγ2-associated antibody deficiency and immune dysregulation (PLAID) and autoinflammation, antibody deficiency, and immune dysregulation (APLAID) (Figures 2B,C). The gene discussed is PLCG2; the disease is autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation.