LPIN2 loss of function in humans leads to Majeed Syndrome, a rare, recessively inherited disorder that is characterized by the triad of early-onset chronic recurrent multifocal osteomyelitis (CRMO), dyserythropoietic anemia (typically microcytic), and neutrophilic skin lesions (Figure 2A) (42, 43). This evidence concerns the gene LPIN2 and chronic recurrent multifocal osteomyelitis.