Thus, instead of pursuing the CXCR3-CXCL9/CXCL10 axis, we decided to focus on the CXCR6-CXCL16 receptor-ligand pair since CXCR6 and CXCL16 have not yet been well-investigated in T1D (41). Here, CXCL16 is linked to type 1 diabetes mellitus.