INS and type 1 diabetes mellitus: Evidence indicates that type I diabetes is induced by a combination of genetic susceptibility [mutation(s) to iddm1, drb1, dqa, and dqb1 gene locus], environmental factors [diet, vitamin D deficiency (Mathieu et al., 2005)], or exposure to a driving antigen (exposure to wheat protein (Knip and Siljander, 2008), antibody from cow's milk protein (Virtanen et al., 1994).