During melanoma evolution, activated macrophages produce TGF-beta (transforming growth factor-beta), TNF-alpha (tumoral necrosis factor-alpha), IL-1 alpha (interleukin-1 alpha), arachidonate metabolites, and extracellular proteases, while melanocytes express IL-8 and VEGF-alpha (vascular endothelial growth factor-alpha), inducing angiogenesis [27]. This evidence concerns the gene TNF and melanoma.