Peroxiredoxins (Prdxs) are antioxidant enzymes emerging as very important in protecting cells against reactive oxygen species (ROS).22 Although their protective role in cardiovascular and neurological diseases is well established, their role in cancer is controversial.23 Considering the oncogenic role of Notch3 in HCC (9), we can assume that its silencing results in over-representation of proteins playing a role of tumour suppressor and down-representation of proteins with a more oncogenic function. This evidence concerns the gene NOTCH3 and cancer.