NOTCH3 and cancer: Conversely, its expression in adult human tissues is limited to the central nervous system, to vascular smooth muscle cells41 and to very few subset of B cells.42 Thus, Notch3 aberrant expression in human cancers represents a promising target for therapeutic treatment.11,16,43,44 Herein, we have shown that Notch3 regulates Aco1, Mdh1 and Idh1, three important enzymes of the TCA cycle leading to brivanib resistance in HCC.