IDH1 and hepatocellular carcinoma: As shown in Fig. 6b, Notch3 silencing in MCF7 and TFK1 cells results in Mdh1, Idh1 and Ido1 down-representation, as observed in HepG2 and Huh7 HCC cell lines, suggesting that Notch3 regulation of metabolic pathways is a common feature in different human cancer cells.