CASP8 and urinary bladder cancer: Moreover, inhibitors of either caspase-3/7 (z-IEVD-fmk) or caspase-8 (z-IETD-fmk) significantly reduced the impact of TYRO3 depletion on cell survival, demonstrating the crucial importance of apoptosis regulation for TYRO3 activity in bladder cancer cells (Fig. 4d).