Moreover, inhibitors of either caspase-3/7 (z-IEVD-fmk) or caspase-8 (z-IETD-fmk) significantly reduced the impact of TYRO3 depletion on cell survival, demonstrating the crucial importance of apoptosis regulation for TYRO3 activity in bladder cancer cells (Fig. 4d). This evidence concerns the gene CASP3 and urinary bladder carcinoma.