RB1 and urinary bladder carcinoma: Given that the pRB pathway is frequently altered in bladder cancer, particularly through direct RB1 gene inactivation, we assessed the impact of TYRO3 depletion in the RB1 mutated bladder cancer cell lines, 5637 (pY325*), 647 V (p.Q383*) and HT1376 (p.Q383*).17 The cell viability of these RB1 mutant cells was significantly decreased upon TYRO3 silencing (Supplementary Figure S8).