TYRO3 knockdown significantly and strongly decreased cell viability in all the cell lines tested, regardless of the expression levels of other TAM receptors (by 60 to 75%, 96 h after transfection, depending on the cell line), demonstrating the high dependence for growth of bladder cancer cell lines on TYRO3 expression and the absence of redundancy with the other TAM receptors (Fig. 2b and Supplementary Table S2). Here, TYRO3 is linked to urinary bladder cancer.