In line with this hypothesis, a phase 1b clinical trial (NCT03170960) has recently begun to test the combination of a pan-TAM inhibitor (cabozantinib) with an anti-PD-L1 antibody (atezolizumab) in patients with advanced urothelial carcinoma (including bladder, renal pelvis, ureter, or urethra carcinoma) or renal cell carcinoma. The gene discussed is CD274; the disease is hereditary clear cell renal cell carcinoma.