Such effects of TYRO3 knockdown have already been reported in other cancer types: melanoma, thyroid and breast cancer cells.25,26,32 In breast cancer cells, as reported here for UBC cells, the regulation of these processes may involve a decrease in CYCLIN D1 and SURVIVIN levels induced by TYRO3 knockdown.32 Our transcriptomic analysis suggested a role for MITF regulation, as previously reported for melanoma,26 but the involvement of MITF in bladder tumours has never been explored. The gene discussed is TYRO3; the disease is urinary bladder neoplasm.