Such effects of TYRO3 knockdown have already been reported in other cancer types: melanoma, thyroid and breast cancer cells.25,26,32 In breast cancer cells, as reported here for UBC cells, the regulation of these processes may involve a decrease in CYCLIN D1 and SURVIVIN levels induced by TYRO3 knockdown.32 Our transcriptomic analysis suggested a role for MITF regulation, as previously reported for melanoma,26 but the involvement of MITF in bladder tumours has never been explored. This evidence concerns the gene BIRC5 and urinary bladder neoplasm.