Recently, it has been shown that silencing endogenous ΔNp63α reduces EGFR expression in triple-negative basal-like breast cancer cells and in pancreatic cancer cells promoting cell growth and chemoresistance.50,51 We thus assessed EGFR expression in HPV-positive and HPV-negative HNC cell lines upon p63 knockdown. The gene discussed is TP63; the disease is familial pancreatic carcinoma.