Purified recombinant HAI-2 (rHAI-2) proteins containing the extracellular region of HAI-2 had been shown to repress prostate and breast cancer cell invasion.7,39 We assessed the effects of rHAI-2 proteins on the cell-surface plasmin, uPA and cell motility of highly invasive CL1-5 and H1299 NSCLC. Here, SPINT2 is linked to breast cancer.