Our study provides novel information on the tumour-suppressor role of the SPARC in the regulation of OvCa-omental cross-talk and highlights the role of overexpression, as well as exogenous recombinant SPARC not only on mitigating the effect of loss of SPARC in adipocytes but on suppressing pro-tumorigenic and metabolic programming, thus making the omental adipocyte niche unfavorable for seeding and colonization of tumour cell. Here, SPARC is linked to neoplasm.