To circumvent this limitation of the mouse model, and to ascertain that our findings are not limited to the phenotype of one cell line or model system, we complemented our mechanistic and phenotypic studies with three human OvCa cell lines in mono- and co-cultures with human omental (pre)adipocytes, as well as human tumour specimens, as well as genetic manipulation of SPARC in human primary omental (pre)adipocytes and human OvCa cells. This evidence concerns the gene SPARC and neoplasm.