Together with our results herein, it is plausible that the effect of SPARC on cancer cell-adipocyte metabolic programming through an effect on SIK2, or through an effect on enzymatic processes that occur in the mitochondria including FA oxidation, leading to significant reactive oxygen species (ROS) generation and activation of the transcriptional inflammatory oncogenic machinery orchestrated by NFkB, cJun, and cEBPβ. The gene discussed is JUN; the disease is cancer.