IL-22 promotes intestinal epithelial regeneration and wound healing.37 A recent study reported that IL-22 promotes fibrogenesis in acute skin wounding,23 but does the opposite in lung fibrosis.38 In the present study, our data revealed that stimulation by recombinant IL-22 promotes the transformation of fibroblasts into myofibroblasts. This evidence concerns the gene IL22 and pulmonary fibrosis.